Haiqing Xu

Tumor suppressor genotype influences the extent and mode of immunosurveillance in lung cancer

This study shows tumor suppressor genotype affects immune cell recruitment and tumor growth in KRAS-driven lung cancer with varying neoantigen expression.

Genetic determinants of gene expression noise and its role in complex trait variation

The paper identifies genetic determinants of gene expression noise and links them to complex trait variation using a large-scale human blood cell dataset.

Functional mapping of epigenetic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes

The paper identifies HBO1 and MLL1 complexes as key tumor suppressors in lung cancer using in vivo functional screens of epigenetic regulators.

Integrative multiomic approaches reveal ZMAT3 and p21 as conserved hubs in the p53 tumor suppression network

The paper identifies ZMAT3 and CDKN1A as key hubs in the p53 tumor suppression network through integrative multiomic analyses in a mouse model.

A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis

This study identifies a STAG2-PAXIP1/PAGR1 tumor-suppressive axis in lung cancer by showing their combined role in suppressing oncogenic KRAS-driven tumorigenesis.