Nicholas Sofos

Genome delivery of a contractile tailed phage and its superinfection exclusion mechanism

This study resolves the structure of bacteriophage T4 at different stages, revealing mechanisms of genome delivery and superinfection exclusion.

Molecular basis of the Druantia anti-phage defense system

This study investigates the molecular mechanism of the Druantia anti-phage defense system, showing that DruH-E provides robust immunity and revealing its DNA unwinding and regulation by ATP.

Structure of a novel contractile injection system in Salmonella enterica subsp. salamae

The paper reports the structure of a novel contractile injection system in Salmonella enterica subsp. salamae and identifies a new CIS cluster.

Structural characterization of an extracellular contractile injection system from Photorhabdus luminescens in extended and contracted states.

This study presents the cryo-EM structures of PlPVC1 in extended and contracted states, revealing structural features and contraction mechanism insights.

Towards a complete phage tail fiber structure atlas.

This paper introduces RBPseg, a method to predict high-confidence tail fiber structures using segmentation and deep learning, and validates it with experimental data and structural classification.