Alexander Harms

This study introduces HIDEN-SEQ, a transposon-insertion sequencing method for phages, to systematically map gene essentiality and uncover previously unknown viral anti-defense factors.

This study resolves the structure of bacteriophage T4 at different stages, revealing mechanisms of genome delivery and superinfection exclusion.

This study investigates the molecular mechanism of the Druantia anti-phage defense system, showing that DruH-E provides robust immunity and revealing its DNA unwinding and regulation by ATP.

The paper introduces Aionostat, an automated device for high-throughput bacteriophage evolution studies, demonstrating its ability to accelerate and standardize phage adaptation and recombination experiments.

The paper completes the BASEL phage collection by overcoming host limitations to isolate new phages, revealing insights into viral host recognition and bacterial immunity.

This study identifies and characterizes two Escherichia coli TAC systems that mediate antiphage defense by recognizing phage proteins and modifying mRNA to inhibit translation.