Author

Alex D. Doan

Fred Hutch Cancer CenterORCID 0000-0002-7247-2256Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

David P MacPhersoniD· 1 shared David SokoloviD· 1 shared Eric Zheng· 1 shared Kristian DavidseniD· 1 shared Lucas B. SullivaniD· 1 shared Madeleine L. HartiD· 1 shared Serwah Danquah· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

David P MacPhersonORCID

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1 paper

Recent·Most cited

Succinate dehydrogenase loss suppresses pyrimidine biosynthesis via succinate-mediated inhibition of aspartate transcarbamylase

Madeleine L. Hart, David Sokolov, Serwah Danquah, Eric Zheng, Alex D. Doan, Kristian Davidsen, David P MacPherson, Lucas B. Sullivan

The paper shows that SDH loss reduces aspartate and increases succinate, inhibiting ATCase and impairing pyrimidine synthesis, leading to replication stress and ATR sensitivity.

Nature Metabolism · May 4, 2026Peer-reviewedCell Biology