Author

Eric Zheng

Fred Hutch Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:metabolomics· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

David SokoloviD· 2 shared Lucas B. SullivaniD· 2 shared Madeleine L. HartiD· 2 shared Serwah Danquah· 2 shared Alex D. DoaniD· 1 shared David P MacPhersoniD· 1 shared Kristian DavidseniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

David SokolovORCID

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2 papers

Recent·Most cited

Adaptive plasticity of aspartate metabolism in succinate dehydrogenase-deficient cancer cells

David Sokolov, Eric Zheng, Serwah Danquah, Madeleine L. Hart, Lucas B. Sullivan

This study identifies two adaptive mechanisms in SDH-deficient cancer cells to overcome aspartate limitation and improve proliferative fitness.

bioRxiv · Jun 17, 2026 · PreprintCancer Biology

Succinate dehydrogenase loss suppresses pyrimidine biosynthesis via succinate-mediated inhibition of aspartate transcarbamylase

Madeleine L. Hart, David Sokolov, Serwah Danquah, Eric Zheng, Alex D. Doan, Kristian Davidsen, David P MacPherson, Lucas B. Sullivan

The paper shows that SDH loss reduces aspartate and increases succinate, inhibiting ATCase and impairing pyrimidine synthesis, leading to replication stress and ATR sensitivity.

Nature Metabolism · May 4, 2026Peer-reviewedCell Biology