David P MacPherson

This paper develops a deep learning framework to infer gene expression from cell-free DNA, improving reliability and enabling functional genomics in precision oncology.

The paper shows that SDH loss reduces aspartate and increases succinate, inhibiting ATCase and impairing pyrimidine synthesis, leading to replication stress and ATR sensitivity.

This study shows that MAX inactivation disrupts the MYC network, leading to neuroendocrine tumors in multiple tissues by altering transcription factor balance.