Identification of a C3b-specific nanobody that does not bind C3 and blocks alternative pathway convertases
Eva M. Struijf, Bart W. Bardoel, Joanne E. van Keulen, Maartje Ruyken, Danique Y. Siere, Douwe J. Dijkstra, Gillian Dekkers, Piet Gros, Raimond Heukers, Dani A. C. Heesterbeek, Suzan H. M. Rooijakkers, Jamie S. Depelteau
This study identifies a C3b-specific nanobody that binds C3b but not C3, and inhibits the alternative pathway convertases of the complement system.
bioRxiv · Sep 3, 2026 · PreprintImmunology