Author

Dani A. C. Heesterbeek

Utrecht UniversityORCID 0000-0003-3100-7275Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Bart W. BardoeliD· 2 shared Suzan H. M. RooijakkersiD· 2 shared Carla J. C. de HaasiD· 1 shared Danique Y. SiereiD· 1 shared Douwe J. DijkstraiD· 1 shared Eva M. StruijfiD· 1 shared Fabian HauseriD· 1 shared Gillian DekkersiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

Bart W. BardoelORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintSep 3, 2026

Identification of a C3b-specific nanobody that does not bind C3 and blocks alternative pathway convertases

Eva M. Struijf, Bart W. Bardoel, Joanne E. van Keulen…·Jamie S. Depelteau

This study identifies a C3b-specific nanobody that binds C3b but not C3, and inhibits the alternative pathway convertases of the complement system.

DOI 10.64898/2026.08.30.748118

humanprotein structure

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MicrobiologyEMBO ReportsPeer-reviewedDec 8, 2025

Bactericidal Membrane Attack Complex formation initiates at the new pole of E. coli

Marije van 't Wout, Fabian Hauser, Philippa I P Holzapfel…·Dani A. C. Heesterbeek

The paper tracks MAC pore localization on E. coli and finds that MAC deposition starts at the new bacterial pole, leading to inner membrane damage and halting division.

2 citations

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