Zihao Chen

This study shows that selective class IIa HDAC inhibition improves diastolic dysfunction in HFpEF without adverse effects.

This paper introduces Festem, a method that directly selects differentially expressed genes for single-cell clustering, improving cell-type identification and reducing selection bias.

This study uses functional ultrasound to monitor brain activity in developing mice and non-human primates, revealing neural activity patterns and responses to external stimuli.

The paper constructs cell-state transition landscapes in melanoma to quantify dynamics of drug resistance, revealing alternative paths like dedifferentiation and hyper-pigmentation, and identifies optimal therapeutic strategies.