Friederike C. Schreiter

Selective class IIa HDAC inhibition reverses diastolic dysfunction in cardiometabolic HFpEF

This study shows that selective class IIa HDAC inhibition improves diastolic dysfunction in HFpEF without adverse effects.

Genomic G quadruplexes regulate mRNA splicing

The paper shows that genomic G quadruplexes regulate mRNA splicing by recruiting RNA-binding proteins, with implications for cardiac function.

Somatic Hdac4-902fs mutations lead to loss of HDAC4 function through nonsense-mediated mRNA degradation

This study shows that somatic HDAC4-902fs mutations cause loss of HDAC4 function via nonsense-mediated mRNA decay, leading to premature ossification and early death in mice.