Author

Shubhadeep Sadhukhan

Weizmann Institute of ScienceORCID 0000-0002-7278-5041Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Nir S. GoviD· 3 shared Aleš IgličiD· 2 shared Samo PeničiD· 2 shared Caitlin E. CornelliD· 1 shared Carsten BetaiD· 1 shared Cristina Martinez-TorresiD· 1 shared Daan VorseleniD· 1 shared Daniel A. FletcheriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiophysics

Nir S. GovORCID

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintAug 3, 2026

A minimal physical model of adhesion-dependent protrusion explains confined haptotaxis and oscillatory cell migration

Jeevan Kumar Papaganti, Jonathan E. Ron, Shubhadeep Sadhukhan…·Nir S. Gov

This paper develops a minimal physical model to explain haptotaxis and oscillatory cell migration by linking adhesion strength to protrusive actin activity.

DOI 10.64898/2026.07.30.741711

statistical modelcell signaling & trafficking

𝕏 PostBluesky

BiophysicsbioRxivPreprintJul 12, 2026

From biting to engulfment: Target mechanics determines modes of phagocytosis through curvature--actin coupling

Shubhadeep Sadhukhan, Caitlin E. Cornell, Mansehaj Kaur Sandhu…·Nir S. Gov

This paper develops a theoretical model to simulate phagocytosis of deformable targets and identifies three mechanical regimes based on target stiffness, validated experimentally with GUVs and lymphoma cells.

DOI 10.64898/2026.01.28.702248

statistical modelcell-cell communication

𝕏 PostBluesky

BiophysicsPhysical Review ResearchPeer-reviewedMar 27, 2025

Modelling how lamellipodia-driven cells maintain persistent migration and interact with external barriers

Shubhadeep Sadhukhan, Cristina Martinez-Torres, Samo Penič…·Nir S. Gov

The paper models cell migration by coupling polarity cues to actin dynamics, showing how long-range inhibition stabilizes motility and explains cellular dynamics.

7 citations

biophysical modelingsynaptic & neural circuits

𝕏 PostBluesky