Carsten Beta

Coiled-coil domain kinking controls laminin-332 cleavage by elastase

This study shows that coiled-coil kinking in laminin-332 directs elastase cleavage to a specific hinge site, ensuring proper fragment generation, while extended conformations lead to random cleavage and degradation.

CaMKIIα holoenzymes self-organize into worm-like mesoscale clusters

This study shows that CaMKII holoenzymes form worm-like mesoscale clusters under spatial confinement, with activation leading to cluster expansion and a mutant variant forming clusters even without activation.

Modelling how lamellipodia-driven cells maintain persistent migration and interact with external barriers

The paper models cell migration by coupling polarity cues to actin dynamics, showing how long-range inhibition stabilizes motility and explains cellular dynamics.

Chemically induced dislocation and mutation of essential cytoskeletal proteins: A case study focusing on Coronin-A

The paper compares four mutation strategies on Coronin-A in Dictyostelium discoideum to assess their effects on actin-dependent processes.