High-throughput quantification of huntingtin mRNA expression and aggregation in mouse brain using automated RNAscope imaging.
Pieter van Velde, Brian Tran, Sarah M. Allen, Eric Luu, Raymond C. Furgal, Ashley Summers, Jillian Belgrad, Emily G. Knox, Anastasia Khvorova, David Grünwald
This study quantifies huntingtin mRNA expression and aggregation in mouse brains using a high-throughput RNAscope pipeline, revealing heterogeneity in mRNA accumulation and localization across brain regions.
bioRxiv · Feb 11, 2026 · PreprintCell Biology