David Grünwald

This study quantifies huntingtin mRNA expression and aggregation in mouse brains using a high-throughput RNAscope pipeline, revealing heterogeneity in mRNA accumulation and localization across brain regions.

This paper proposes tiered metadata specifications for light microscopy to improve data quality, reproducibility, and interoperability, inspired by genomic standards like Encode.

Micro-Meta App is an open-source tool that helps collect and organize microscopy metadata according to community standards, improving reproducibility and data sharing.

The paper reports that RNAi-induced relocalization of target RNA to P granules could not be replicated by independent researchers.

The paper introduces an automated Bayesian pipeline for analyzing single-molecule binding data and benchmarks it using TtAgo binding properties.

The paper explains an unexplained discrepancy in photon count ratios used to estimate axial position in single-molecule localization microscopy and shows susceptibility to optical aberrations.