Scott Waddell

This paper shows how hunger reconfigures a reward circuit in Drosophila to support memory formation by switching dopamine neuron activity modes.

This study shows dietary magnesium enhances memory by modulating Hippo signaling in Drosophila neurons, specifically in β Kenyon Cells.

This study shows that dopaminergic neurons in Drosophila encode steering signals in both allocentric and egocentric coordinates during goal-directed navigation.

The paper identifies a reproductive checkpoint in Drosophila that links ovarian relaxin to maternal gut plasticity via genetic sex and steroid signaling.

The paper shows that post-ingestive malaise in Drosophila updates memories by modulating dopaminergic and serotoninergic neurons through Toll signaling.

The paper identifies a feed-forward swallowing circuit in Drosophila that links protein deprivation to prolonged feeding bursts by coordinating swallowing motor neurons through a Sustain neuron.

This study identifies a mechanism by which octopamine modulates memory expression in Drosophila by prioritizing recent over long-term memories through specific neural circuits.

This study identifies VGLUT-mediated mechanisms protecting DA neurons from PD-related degeneration, revealing sex-specific effects and transcriptional regulators.

The paper identifies D-serine release from astrocytes as a mechanism promoting thirst-directed behaviors in Drosophila by activating glutamatergic circuits.

This study identifies CMTr1 and CMTr2 as cap-adjacent 2'-O-ribose methyltransferases essential for reward learning and synaptic mRNA localization in Drosophila.

This study identifies how different dopaminergic neurons in Drosophila encode absolute and relative aversive value through distinct mechanisms in the mushroom body network.

The paper localizes specific mRNAs in Drosophila Mushroom Body Output Neurons before and after aversive olfactory learning, showing cell-specific abundance and a transient increase in CaMKII mRNA.

This study shows that odor pre-exposure in Drosophila creates an aversive memory that inhibits appetitive olfactory memory, requiring specific dopaminergic neurons and context similarity.

The paper maps transposon expression in Drosophila midbrain using single-cell RNA sequencing and identifies chimeric transposon-gene mRNAs that expand the neural transcriptome.

The paper maps the synaptic connectivity of the Drosophila mushroom body and identifies new circuit components and structures in sensory input processing and output modulation.

The paper reconstructs the complete connectome of olfactory projection neurons in the Drosophila brain and identifies new connectivity patterns in olfactory circuits.

The paper identifies anatomical subtypes of dopaminergic neurons in Drosophila and their specific input connectivity, revealing functional roles in reinforcement and memory.

The paper creates a single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord, identifying over 100 transcriptionally distinct cell types.

The paper shows spaced training in Drosophila creates both aversive and safety memories, enhancing long-term memory performance through complementary memory formation.

The paper uses single-cell transcriptomics to characterize cellular diversity in the Drosophila midbrain, identifying cell types based on neurotransmitter and neuromodulator expression.

This paper introduces an adaptive two-photon microscope for rapid volumetric neural activity recording in live Drosophila brains, enabling calcium transient imaging in mushroom body Kenyon cells despite motion.

This paper applies single-molecule FISH to study post-transcriptional regulation in Drosophila brains by analyzing mRNA distributions and co-visualizing transcripts and proteins.