Paul François

The paper investigates how temperature cycles affect medaka embryonic development, revealing temperature-insensitive spatial patterns that compensate for temperature-sensitive temporal oscillations.

The paper shows that oscillatory co-expression of HES1 and HES5 allows hybrid states in a bistable transcription factor motif by enabling phase-locking and entrainment.

This paper develops a phase model to explain self-organized concentric wave patterns in embryonic oscillators, showing that excitability and coupling function shape these patterns.

This study introduces a generative model to infer epigenetic landscapes from data, demonstrating its application in developmental biology examples.

The paper shows that manifold learning, implemented via inhibitory interneurons with IBCM plasticity, enables olfactory habituation to fluctuating backgrounds better than mean subtraction methods.

The paper identifies division asymmetry as the main driver of cell size variability in budding yeast, showing it outweighs G1/S size control effects.

The paper confirms the Product neutrality function accurately predicts double mutant fitness in budding yeast and shows it emerges from mechanistic models of cell growth.

This paper develops a dynamical model of the immune system that supports the discontinuity theory by showing how immune responses depend on the rate of antigenic change, with implications for infections and vaccination.

The paper identifies non-reciprocal synchronization rules in embryonic oscillator ensembles using a novel experimental assay and develops a new coupling model called Rectified Kuramoto.

The paper simulates the evolution of cell size control mechanisms and finds that adders or sizers emerge based on cell cycle structure and selective pressures.

The paper uses a coarse-grained theoretical-experimental approach to study the dynamics of the mouse embryonic segmentation clock, revealing its non-linear oscillator characteristics and long-term feedbacks.

The paper quantifies tissue behavior during amniote embryo axis elongation using 4D imaging and analysis techniques, revealing coordinated tissue movements and the central role of the PSM in elongation.