Charles Pyke

This study shows semaglutide reduces neuroinflammation in mice by modulating microglia, endothelial cells, and pericytes, with implications for neurodegenerative diseases.

This study identifies 20 GWAS risk genes in smooth muscle cells linked to coronary artery disease and reveals shared disease mechanisms across different gene types.

This study benchmarks three deconvolution methods in spatial transcriptomics for cardiovascular and kidney diseases, finding comparable performance with method-specific trade-offs.

The paper integrates single-cell RNA-seq and spatial transcriptomics data to reveal cellular interactions and changes in human atherosclerosis.

The paper presents HYPOMAP, a comprehensive spatio-cellular map of the human hypothalamus, identifying BMI-associated genes and potential druggable targets.

The paper uses single-nucleus RNA sequencing to analyze the mouse hindbrain's AP and NTS in fed and fasted states, identifying transcriptional changes and receptor expression patterns relevant to obesity therapies.