Author

Joseph Polex-Wolf

Novo Nordisk (Denmark)ORCID 0000-0002-0441-8872Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:mouse· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:clustering· 1 Approach:experimental assay· 1

Frequent Co-Authors

Brian LamiD· 3 shared Charles PykeiD· 3 shared Giles S.H. YeoiD· 3 shared Lotte Bjerre KnudseniD· 3 shared Anthony P. ColliD· 2 shared Debra RimmingtoniD· 2 shared Georgina K.C. DowsettiD· 2 shared Irène CiminoiD· 2 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersNeuroscience

Brian LamORCID

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Author profile →

4 papers

Recent·Most cited

Semaglutide Attenuates Neuroinflammation in Mice

Dylan M. Belmont-Rausch, Mette Q. Ludwig, Marie Aare Bentsen, Stine Normann Hansen, Anna Secher, Dorte Holst, Jaime Moreno, Vivek Das, Kristoffer Lihme Egerod, Anne-Mette Bjerregaard, Kristoffer Niss, S. Sherona Bau, Charles Pyke, Kevin Dalgaard, Myrte Merkestein, , Tune H. Pers

This study shows semaglutide reduces neuroinflammation in mice by modulating microglia, endothelial cells, and pericytes, with implications for neurodegenerative diseases.

bioRxiv · Jan 12, 2026 · PreprintNeuroscience

Human HYPOMAP: A comprehensive spatio-cellular map of the human hypothalamus

John A. Tadross, Lukas Steuernagel, Georgina K.C. Dowsett, Katherine A. Kentistou, Sofia Hult Lundh, Marta Porniece, Paul Klemm, Kara Rainbow, Henning Hvid, Katarzyna Kania, Joseph Polex-Wolf, Lotte Bjerre Knudsen, Charles Pyke, John R. B. Perry, Brian Lam, , Giles S.H. Yeo

The paper presents HYPOMAP, a comprehensive spatio-cellular map of the human hypothalamus, identifying BMI-associated genes and potential druggable targets.

bioRxiv · Sep 15, 2023 · PreprintNeuroscience

A survey of the mouse hindbrain in the fed and fasted state using single-nucleus RNA sequencing

Georgina K.C. Dowsett, Brian Lam, John A. Tadross, Irène Cimino, Debra Rimmington, Anthony P. Coll, Joseph Polex-Wolf, Lotte Bjerre Knudsen, Charles Pyke, Giles S.H. Yeo

The paper uses single-nucleus RNA sequencing to analyze the mouse hindbrain's AP and NTS in fed and fasted states, identifying transcriptional changes and receptor expression patterns relevant to obesity therapies.

Molecular Metabolism · May 4, 2021Peer-reviewedNeuroscience

Heterogeneity of hypothalamic Pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing

Brian Lam, Irène Cimino, Joseph Polex-Wolf, Sara Kohnke, Debra Rimmington, Valentine Iyemere, Nicholas Heeley, Chiara Cossetti, Reiner Schulte, Luís R. Saraiva, Darren W. Logan, Clémence Blouet, Stephen O’Rahilly, Anthony P. Coll, Giles S.H. Yeo

The paper uses single-cell RNA sequencing to reveal heterogeneity in murine hypothalamic POMC neurons, identifying distinct subpopulations with different gene expression profiles and receptor expression.

Molecular Metabolism · Mar 1, 2017Peer-reviewedNeuroscience