John A. Tadross

This study develops human epithelioids as a 3D culture system that maintains architecture, heterogeneity, and clonal evolution over time, enabling long-term studies of tissue dynamics and therapeutic responses.

This study shows MRAP2 interacts with MC3R to enhance its signaling, affecting energy homeostasis and obesity risk.

This study identifies damaging LXRα mutations linked to reduced triglycerides but increased liver enzyme levels and hepatotoxicity, suggesting LXR's role in liver health and cautioning against its inhibition for MASLD treatment.

This study investigates how GLP-1R agonists affect human hypothalamic neurons derived from pluripotent stem cells, finding they induce depolarization, increased firing, and gene expression changes.

The paper presents HYPOMAP, a comprehensive spatio-cellular map of the human hypothalamus, identifying BMI-associated genes and potential druggable targets.

The paper uses single-nucleus RNA sequencing to analyze the mouse hindbrain's AP and NTS in fed and fasted states, identifying transcriptional changes and receptor expression patterns relevant to obesity therapies.

This paper develops a gene expression signature, Cam_121, to predict long-term outcomes in primary melanoma patients, showing improved accuracy compared to clinical and existing prognostic models.

The paper shows that refeeding after fasting rapidly activates oligodendrocyte differentiation in the hypothalamic median eminence, altering extracellular matrix proteins and using mTORC1 signaling to monitor nutritional signals.