A priority code in presequences: mitochondrial targeting signals assign specific import characteristics to precursor proteins
Saskia Rödl, Yasmin Hoffman, Felix Jung, Annika Egeler, Annika Nutz, Oliver Šimončík, Martin Jung, Markus Räschle, Petr Müller, Zuzana Štorchová, Timo Mühlhaus, Johannes M. Herrmann
The paper classifies mitochondrial presequences into seven groups and identifies group A presequences as enhancing import efficiency through a specific targeting mechanism involving TOMM34.
PLoS Biology · Jul 21, 2025Peer-reviewedBiochemistry