Annika Nutz

Presequences of non-imported mitochondrial proteins serve as quality control elements in the cytosol

This study shows that mitochondrial presequences function in cytosolic quality control and trigger a heat shock response when mitochondrial import is inhibited.

The mitochondrial cohibitin complex facilitates the biogenesis of inner membrane proteins

The paper identifies the cohibitin complex, including Aim11, as a quality control factor that supports TIM22-mediated insertion of carrier proteins into the mitochondrial inner membrane.

The ribosome-associated complex regulates cytosolic translation upon mitoprotein-induced stress

The paper shows that Zuo1, a ribosome-associated complex chaperone, mitigates growth defects and translation reduction in yeast with mitochondrial import defects under heat stress.

A priority code in presequences: mitochondrial targeting signals assign specific import characteristics to precursor proteins

The paper classifies mitochondrial presequences into seven groups and identifies group A presequences as enhancing import efficiency through a specific targeting mechanism involving TOMM34.