The paper expands the concept of MHC Class I peptide binding promiscuity to support vaccine discovery across cancers by analyzing data from 2,323 samples.

bioRxiv · May 8, 2025 · PreprintBioinformatics

Microenvironment of metastasis reveals key predictors of PD-1 blockade response in renal cell carcinoma

Florian Jeanneret, Pauline Bazelle, Sarah Schoch, Catherine Pillet, In Hwa Um, Assilah Bouzit, Bertrand Evrard, Evan Seffar, Frédéric Chalmel, Javier A. Alfaro, Cátia Pesquita, Fabio Massimo Zanzotto, Mark D. Stares, Stefan Nicholas Symeonides, Alexander Laird, , Christophe Battail

The paper identifies key predictors of PD-1 blockade response in renal cell carcinoma by analyzing the tumor microenvironment of metastatic sites and developing a predictive TID score.

bioRxiv · Jul 17, 2023 · PreprintBioinformatics

The immunopeptidome from a genomic perspective: Establishing immune-relevant regions for cancer vaccine design

Georges Bedran, Tongjie Wang, Dominika Pankanin, Kenneth Weke, Alexander Laird, Christophe Battail, Fabio Massimo Zanzotto, Cátia Pesquita, Håkan Axelson, Ajitha Rajan, David James Harrison, Aleksander Pałkowski, Maciej Pawlik, Maciej Parys, J. Robert O’Neill, , Javier A. Alfaro

The paper develops COD-dipp to map MHC Class I antigens from cancer studies and identifies immune-relevant genomic regions for vaccine design.

bioRxiv · Jan 13, 2022 · PreprintBioinformatics