An ultra-long heavy chain bovine antibody neutralizes SARS-CoV-2 and reacts broadly with sarbecoviruses.
Theocharis Tsoleridis, Chengcheng Fan, Emily J. Park, Joshua D. Duncan, Parul Sharma, Sophie Wartnaby, Joseph G. Chappell, Anja Kipar, Eleanor G. Bentley, Adam Kirby, Ximeng Han, Christopher M. Coleman, Igor Andrade Santos, Dalan Bailey, Andrew I. Flyak, , Jonathan K. Ball
This study identifies two bovine-derived monoclonal antibodies with ultra-long CDRH3 domains that broadly neutralize SARS-CoV-2 and sarbecoviruses.
bioRxiv · Jan 3, 2025 · PreprintImmunology