Chengcheng Fan

This study identifies nanobodies targeting conserved SARS-CoV-2 RBD epitopes that neutralize variants and zoonotic sarbecoviruses.

This study evaluates bivalent S-EABR mRNA-LNP boosters in pre-vaccinated mice, showing enhanced neutralizing responses and polyclass RBD antibody diversity against SARS-CoV-2 variants.

The paper identifies ACE2 as a receptor for HKU5 coronaviruses from Pipistrellus abramus bats and investigates receptor tropism across merbecovirus clades.

This paper develops mosaic RBD-nanoparticles to induce cross-reactive anti-sarbecovirus antibodies in animals, demonstrating their effectiveness against SARS-CoV-2 variants and zoonotic viruses.

This study identifies two bovine-derived monoclonal antibodies with ultra-long CDRH3 domains that broadly neutralize SARS-CoV-2 and sarbecoviruses.

The paper shows mosaic-8b nanoparticles induce broader cross-reactive antibodies than homotypic ones, even in pre-vaccinated animals, suggesting potential for improved vaccine design against emerging sarbecoviruses.

iAChSnFR, a fluorescent indicator built from a bacterial periplasmic binding protein, reports acetylcholine with large, fast signals in mouse, fish, fly and worm preparations.