Michael Hecht-Bucher

The Shewanella oneidensis Fic enzyme SoFic targets the switch-Iregion of EF-Tu for AMPylation

This study identifies EF-Tu as a target of the Fic enzyme SoFic, showing AMPylation disrupts EF-Tu's switch-I region and inhibits translation, while SoFic also binds DNA, suggesting dual regulatory roles.

SHANK3-CAMSAP2 interaction links synapses to dendritic microtubule organisation in PV neurons

The paper shows that the SHANK3-CAMSAP2 interaction links synapses to dendritic microtubule organisation in parvalbumin neurons, with the SHANK3L68P mutation enhancing this interaction and altering microtubule dynamics.

Discovery of a new evolutionarily conserved short linear F-actin binding motif

The paper identifies a new evolutionarily conserved short linear F-actin binding motif and develops a computational pipeline to identify its containing proteins.

Non-canonical function of ADAM10 in presynaptic plasticity

This study identifies ADAM10's localization to presynaptic vesicles and shows its role in synaptic facilitation through interaction with synaptotagmin 7, independent of its proteolytic activity.

Autism associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses

This study shows two ASD-associated SHANK3 mutations cause structural changes and altered protein turnover at synapses.