Xiangbo Ruan

This study identifies hLMR1, a human-specific lncRNA, as a suppressor of hepatic amino acid catabolism and ureagenesis, linking its dysregulation to metabolic dysfunction in MAFLD.

The paper shows that human HuR suppresses fatty acid catabolism genes by blocking pre-mRNA processing, which may explain reduced efficacy of PPAR agonists in human fatty liver disease.

This study examines post-transcriptional regulation in fatty liver progression using RNA-seq data from mice, finding decreased NMD activity correlates with severe fatty liver.

The paper introduces lncRNAKB, a comprehensive knowledgebase of 77,199 human lncRNAs with expression, conservation, and cis-eQTL data from GTEx.