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Scientific DataBioinformaticsPeer-reviewed journal article

lncRNAKB: A comprehensive knowledgebase of long non-coding RNAs

Fayaz SeifuddiniD, Komudi SinghiD, Abhilash SureshiD, Jennifer JudyiD, Yun-Ching CheniD, Vijender Chaitankar, Ilker TunciD, Xiangbo RuaniD, Ping LiiD, Yi CheniD, Haiming CaoiD, Richard S. LeeiD, Fernando S. GoesiD, Peter P. ZandiiD, Mohsin Saleet JafriiD, Mehdi PiroozniaiD

PDFDOIPreprint

Abstract

We have assembled a comprehensive long non-coding RNA knowledgebase (lncRNAKB) of 77,199 annotated human lncRNAs (224,286 transcripts) by methodically integrating widely used lncRNAs resources. To facilitate functional characterization of lncRNAs, we employed Genotype-Tissue Expression (GTEx) project to provide tissue-specific gene expression profiles of lncRNAs in 31 solid organ tissues. Additional information includes network analysis to identify co-expressed gene modules to potentially delineate lncRNA function. Tissue-specificity, phylogenetic conservation scores and coding potential for lncRNAs are included. Finally, using whole genome sequencing data from GTEx, expression quantitative trait loci (cis-eQTL) regulated lncRNAs were calculated in all tissues. lncRNAKB is available at http://www.lncrnakb.org.

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