Shohei Takaoka

Suppression of hepatic amino acid catabolism by the human-specific lncRNA hLMR1

This study identifies hLMR1, a human-specific lncRNA, as a suppressor of hepatic amino acid catabolism and ureagenesis, linking its dysregulation to metabolic dysfunction in MAFLD.

Human-Specific Suppression of Hepatic Fatty Acid Catabolism by RNA-Binding Protein HuR

The paper shows that human HuR suppresses fatty acid catabolism genes by blocking pre-mRNA processing, which may explain reduced efficacy of PPAR agonists in human fatty liver disease.

Disrupted Post-Transcriptional Regulation of Gene Expression as A Hallmark of Fatty Liver Progression

This study examines post-transcriptional regulation in fatty liver progression using RNA-seq data from mice, finding decreased NMD activity correlates with severe fatty liver.

Post-transcriptional regulation by the CCR4-NOT deadenylase complex maintains redox homeostasis in insulin biosynthesis in mouse pancreatic β cells

The paper shows that CNOT7 deletion in mouse pancreatic β cells reduces insulin content and secretion by impairing proinsulin conversion, through reduced PRDX4 and increased CNOT8 binding to Prdx4 mRNA via MSI2.