Typhoid toxin of Salmonella enterica induces ISG15 response mediating host cell survival and bacterial dissemination
Daniel S Stark, Michelle King, Angela EM Ibler, Nadia Baseer, Ellen G Vernon, Yifeng Zhang, Christopher Staples, Lilliana Radoshevich, Daniel Humphreys
This study identifies ISG15 as a key host defense mechanism against Salmonella typhoid toxin, showing it promotes cell survival and reduces bacterial burden through a STING-dependent pathway.
bioRxiv · Apr 29, 2025 · PreprintMicrobiology