Damon Huber

AscA (YecA) is a molecular chaperone involved in Sec-dependent protein translocation in Escherichia coli

This paper identifies AscA (YecA) as a novel molecular chaperone that facilitates Sec-dependent protein translocation in E. coli by interacting with SecB and ribosomes.

Genetic screen suggests an alternative mechanism for azide-mediated inhibition of SecA

The paper uses a genetic screen to show azide inhibits SecA by causing it to backtrack in its ATPase cycle, disrupting membrane and metal cofactor binding.

Evidence for phospholipid export from the gram-negative inner membrane: time to rethink the Mla pathway?

The paper solves the crystal structure of MlaC and shows the Mla pathway exports phospholipids from the inner membrane to the periplasm, challenging the previous belief in retrograde transport.