Macroscopic to Ultrastructural Analyses Identify the Loss of Myofibrils as the Primary Mediator of Muscle Fiber Atrophy in Aging and Disuse
Ramy K. A. Sayed, Anthony N. Lange, Hector G. Paez, Jamie E. Hibbert, Marius Meinhold, Corey G. K. Flynn, Matilde B.Z. Vergara, Isabell Dobrzycki, David J. Wrucke, Carlos S. Zepeda, Jessica J. James, Christopher W. Sundberg, Troy Alan Hornberger
This study identifies myofibril loss as the primary cause of muscle fiber atrophy in aging and disuse, using macroscopic to ultrastructural analyses in humans and mice.
bioRxiv · Feb 18, 2026 · PreprintPhysiology