Troy Alan Hornberger

Mechanical Loading Induces the Radial Growth of Myofibrils and Myofibrillogenesis via an mTORC1-Dependent Mechanism

This study shows that mTORC1 regulates myofibrillogenesis and radial myofibril growth in response to mechanical loading in mice.

TAK1 regulates skeletal muscle mass, hypertrophic signaling, and metabolic homeostasis in male and female mice

This study shows TAK1 regulates skeletal muscle mass, hypertrophy, and metabolism in both male and female mice by affecting signaling pathways and gene expression.

Macroscopic to Ultrastructural Analyses Identify the Loss of Myofibrils as the Primary Mediator of Muscle Fiber Atrophy in Aging and Disuse

This study identifies myofibril loss as the primary cause of muscle fiber atrophy in aging and disuse, using macroscopic to ultrastructural analyses in humans and mice.

Mechanical Loading Induces the Longitudinal Growth of Muscle Fibers via an mTORC1-Independent Mechanism

This study shows mechanical loading induces muscle fiber growth through two mechanisms: mTORC1-dependent radial growth and mTORC1-independent longitudinal sarcomere addition.

Rapamycin does not compromise physical performance or muscle hypertrophy after PoWeR while intermittent rapamycin alleviates glucose disruptions by frequent rapamycin

This study investigates how different rapamycin dosing schedules affect physical performance and metabolic outcomes in mice undergoing voluntary exercise training.