Thomas Helleday

A high-throughput screening dataset of small-molecule inhibitors across human DNA glycosylases

The paper establishes a high-throughput screening dataset of small-molecule inhibitors across nine human DNA glycosylases, identifying previously unreported inhibitors and making data publicly available.

RareFoldGPCR: Agonist Design Beyond Natural Amino Acids

RareFoldGPCR designs peptide agonists using noncanonical amino acids to modulate GPCRs, validated experimentally for functional activity.

Blind De Novo Design of Dual Cyclic Peptide Agonists Targeting GCGR and GLP1R

This paper designs cyclic peptide agonists for GCGR and GLP1R using EvoBind, achieving dual activation with EC50 values comparable to natural hormones.

The spatial landscape of clonal somatic mutations in benign and malignant tissue

The paper uses spatial transcriptomics to analyze copy number variations in benign and malignant tissues, revealing clonal patterns and suggesting early cancer evolution mechanisms.