Author

Clara Sanchez

Centre National de la Recherche ScientifiqueORCID 0000-0002-7385-0191Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Carole RovèreiD· 2 shared Céline CanselliD· 2 shared Alexandre BénaniiD· 1 shared Arnaud PolizziiD· 1 shared Bruno PatrisiD· 1 shared Carole Rovere· 1 shared Clémence BlouetiD· 1 shared Doriane TrompieriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersPhysiology

Carole RovèreORCID

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3 papers

Recent·Most cited

Postprandial hypertriglyceridemia activates microglia to promote satiety via an ASC dependent signaling.

Juliette Salvi, Emmanuelle Nédélec, Lucie Leret, Fabienne Liénard, Tatiana Landré, Selma Ben Fradj, Valentin Garcia, Vincent Gigot, Bruno Patris, Vivien Pires, Arnaud Polizzi, Clara Sanchez, Thomas Gautier, Hervé Guillou, Tony Heurtaux, , Alexandre Bénani

This study shows that postprandial hypertriglyceridemia activates microglia to promote satiety via an ASC-dependent signaling pathway, which is sexually dimorphic and disrupted in obesity.

bioRxiv · Oct 13, 2026 · PreprintNeuroscience

"Smurf Mice": revolutionising our understanding of age-related and end-of-life animal physiology

Céline Cansell, Vivien Goepp, Fanny Bain, Nicolas Todd, Véronique Douard, Magali Monnoye, Flaminia Zane, Clara Sanchez, Nicolas Pietrancosta, Carole Rovère, R Denis, Serge H. Luquet, Michaël Rera

This paper validates a two-phase ageing model in mice, showing a phenotypic signature of imminent death across chronological ages.

bioRxiv · Jun 14, 2025 · PreprintPhysiology

Computational detection, characterization, and clustering of microglial cells in a mouse model of fat-induced postprandial hypothalamic inflammation

Clara Sanchez, Morgane Nadal, Céline Cansell, Sarah Laroui, Xavier Descombes, Carole Rovère, Éric Debreuve

This paper introduces an automated algorithm to detect and cluster microglial cells in mouse hypothalamic tissue, revealing morphological subpopulations affected by high-fat diet.

Methods · Feb 26, 2025Peer-reviewedNeuroscience