Nicolas Pietrancosta

Temporal tuning of actin nucleation by the repurposed DNA repair complex RAD51/fignl1 encodes distinct axon guidance decisions

The paper shows how RAD51/fignl1, repurposed from DNA repair, controls axon guidance by modulating F-actin nucleation timing and magnitude.

Focal drug uncaging for the precise control of endogenous nicotinic receptors in behaving mice

This paper introduces a method to control endogenous nicotinic receptors in mice using light-activated drug release, revealing circuit-specific effects previously hidden by systemic administration.

Exploring the multi-protein assembly of the enzymes of the de novo purine nucleotide biosynthetic pathway from Pseudomonas aeruginosa

This study investigates the structural and functional organization of the de novo purine nucleotide biosynthetic pathway enzymes in Pseudomonas aeruginosa, revealing a metabolon-like complex with potential antibiotic implications.

NKCC1 as a signaling hub regulating KCC2 stability, chloride homeostasis, and seizure susceptibility

The paper identifies NKCC1 as a signaling hub that regulates KCC2 stability and chloride homeostasis, showing that peptides targeting NKCC1 can reduce seizure frequency in epilepsy.

"Smurf Mice": revolutionising our understanding of age-related and end-of-life animal physiology

This paper validates a two-phase ageing model in mice, showing a phenotypic signature of imminent death across chronological ages.

A tunable and versatile chemogenetic near infrared fluorescent reporter

The paper introduces nirFAST, a tunable NIR fluorescent reporter for multiplexed imaging, enabling subdiffraction resolution and cell cycle monitoring in live cells.

Engineering of a fluorescent chemogenetic reporter with tunable color for advanced live-cell imaging

The paper engineers a fluorescent chemogenetic reporter with tunable color for live-cell imaging, enabling advanced spectral control and compatibility with advanced imaging techniques.