Tony Heurtaux

Postprandial hypertriglyceridemia activates microglia to promote satiety via an ASC dependent signaling.

This study shows that postprandial hypertriglyceridemia activates microglia to promote satiety via an ASC-dependent signaling pathway, which is sexually dimorphic and disrupted in obesity.

Voluntary Exercise Differentially Affects High-Fat Induced Metabolic Phenotypes Across BXD Mouse Strains

The paper shows that voluntary exercise improves glucose tolerance in some BXD mouse strains on a high-fat diet, independent of caloric intake, and suggests gut microbiota may mediate this effect.

Park7 deletion leads to age- and sex-specific transcriptome changes involving NRF2-CYP1B1 axis in mouse midbrain astrocytes

The paper shows that Park7 deletion causes sex-specific transcriptome changes in male mouse midbrain astrocytes via the NRF2-CYP1B1 axis, affecting oxidative stress and EMT processes.

Dietary fibre deprivation and bacterial curli exposure shift gut microbiome and exacerbate Parkinson's disease-like pathologies in an alpha-synuclein-overexpressing mouse

This study shows that dietary fibre deprivation and bacterial curli exposure worsen PD-like symptoms in mice overexpressing human alpha-synuclein.

Neurodegeneration and neuroinflammation are linked, but independent of alpha-synuclein inclusions, in a seeding/spreading mouse model of Parkinson disease

The paper investigates the role of alpha-synuclein spreading and inclusions in Parkinson disease using a mouse model, finding that neurodegeneration and microgliosis occur independently of inclusions.