Sandra Montes-Olivas

This study develops an algorithm for counting crypt-like structures in intestinal organoids and modifies a 2D agent-based model to better simulate budding structures, showing improved agreement with experimental data.

The paper develops an agent-based model to study the interaction between Hippo and Wnt signaling pathways in intestinal crypts, showing Hippo reduces β-catenin and slows crypt turnover, and division-based Wnt spreading can form gradients.

The paper develops a dual-input system to dynamically regulate gene expression and protein stability in mouse embryonic stem cells, enabling precise control of protein levels and faster response times.