PathologybioRxivPreprint
Dual-action nanoconjugate for overcoming r-tPA -resistant clots
Audrey Picot, Mandy Leboucher, Charly Hélaine…·Thomas Bonnard
This study develops a dual-action nanoconjugate combining r-tPA and DNase to target r-tPA-resistant clots, showing improved reperfusion and reduced lesion volume in an ischemic stroke model.