Author

Madhumalar Subramanian

Masaryk UniversityORCID 0000-0002-7433-3073Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

David BednářiD· 2 shared Jiřı́ DamborskýiD· 2 shared Joan Planas-IglesiasiD· 2 shared Martin MarekiD· 2 shared Zbyněk ProkopiD· 2 shared Aliaksandra KursitiD· 1 shared Aneta Vaskova· 1 shared Anthony LegrandiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

David BednářORCID

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2 papers

Recent·Most cited

Taurine Inhibits Apolipoprotein E4 Aggregation

Anthony Legrand, Kateřina Amruz Černá, Sérgio M. Marques, Naina Verma, Jakub Kopko, Tereza Váňová, Madhumalar Subramanian, Aliaksandra Kursit, Jaroslav M. Bendl, Tomas Henek, Pavel Vaňáček, Josef Kučera, Joan Planas-Iglesias, Jiří Sedmík, Veronika Pospíšilová, , Zbyněk Prokop

This study shows taurine inhibits ApoE4 aggregation and reduces its pathophysiological effects, similar to tramiprosate and 3-sulfopropanoic acid.

Biomedicine & Pharmacotherapy · May 1, 2026Peer-reviewedBiochemistry

Prediction of Aggregation Prone Regions in Proteins Using Deep Neural Networks and Their Suppression by Computational Design

Vojtěch Cima, Antonín Kunka, Joan Planas-Iglesias, Ekaterina Grakova, Martin Havlásek, Madhumalar Subramanian, Michal Běloch, Martin Marek, Kateřina Slaninová, Jiřı́ Damborský, Zbyněk Prokop, David Bednář, Jan Martinovič

This paper develops a deep neural network predictor, AggreProt, to identify aggregation-prone regions in proteins and demonstrates its utility in designing mutations to suppress aggregation.

bioRxiv · Mar 6, 2024 · PreprintBioinformatics