Author

Anthony Legrand

Masaryk UniversityORCID 0000-0002-3500-2298Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

David BednářiD· 3 shared Jiřı́ DamborskýiD· 3 shared Joan Planas-IglesiasiD· 3 shared Lenka HernychováiD· 3 shared Martin MarekiD· 3 shared Zbyněk ProkopiD· 3 shared Dáša BohačiakováiD· 2 shared Jiří SedmíkiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

David BednářORCID

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Author profile →

3 papers

Recent·Most cited

Taurine Inhibits Apolipoprotein E4 Aggregation

Anthony Legrand, Kateřina Amruz Černá, Sérgio M. Marques, Naina Verma, Jakub Kopko, Tereza Váňová, Madhumalar Subramanian, Aliaksandra Kursit, Jaroslav M. Bendl, Tomas Henek, Pavel Vaňáček, Josef Kučera, Joan Planas-Iglesias, Jiří Sedmík, Veronika Pospíšilová, , Zbyněk Prokop

This study shows taurine inhibits ApoE4 aggregation and reduces its pathophysiological effects, similar to tramiprosate and 3-sulfopropanoic acid.

Biomedicine & Pharmacotherapy · May 1, 2026Peer-reviewedBiochemistry

Investigating the Conformational Flexibility of Staphylokinase Across Multiple Time Scales

Anthony P. Legrand, Linda Kasiarova, Naina Verma, Jan Mičan, Joan Planas-Iglesias, Pavel Kohout, Alan Strunga, Josef Kučera, Tomas Henek, Pavel Vaňáček, Tim de Martines, Pavel Kadeřávek, Lukáš Žı́dek, Jiřı́ Damborský, Stanislav Mazurenko, , Martin Marek

This study investigates the conformational flexibility of staphylokinase variants to explain their reduced immunogenicity and altered properties.

bioRxiv · Feb 6, 2026 · PreprintBiochemistry

Domino-like Effect of C112R Mutation on APOE4 Aggregation and Its Reduction by Alzheimer's Disease Drug Candidate

Michal Nemergut, Sérgio M. Marques, Lukáš Uhrík, Tereza Váňová, Markéta Nezvedová, Darshak Chandulal Gadara, Durga Jha, Jan Tulis, Veronika Novakova, Joan Planas-Iglesias, Antonín Kunka, Anthony Legrand, Hana Hříbková, Veronika Pospíšilová, Jiří Sedmík, , Martin Marek

The paper investigates how the C112R mutation in ApoE4 causes aggregation and shows that tramiprosate reduces this aggregation.

bioRxiv · Oct 9, 2022 · PreprintNeuroscience