Martin Marek

This study uses ultrahigh-throughput screening to identify mutations in dehalogenases that modulate substrate access and binding, revealing distal functional effects on enzyme dynamics.

This paper develops a cumate-inducible model to study MYC-driven neuroblastoma and identifies mitoribosomal synthetic lethality as a therapeutic target in MYC(N)-amplified tumors.

This paper designs next-generation thrombolytic proteases with improved catalytic efficiency, fibrin selectivity, and inhibition resistance through multi-objective enzyme engineering.

This study reports co-crystal structures of a bioluminescent energy-transfer complex in Renilla reniformis, revealing the spatial arrangement of donor-acceptor chromophores and their role in efficient radiationless energy transfer.

This study characterizes the conformational states of human plasminogen using structural biology techniques, revealing closed and open conformations in recombinant and plasma-derived variants.

This study shows taurine inhibits ApoE4 aggregation and reduces its pathophysiological effects, similar to tramiprosate and 3-sulfopropanoic acid.

This study investigates the conformational flexibility of staphylokinase variants to explain their reduced immunogenicity and altered properties.

This paper shows that replacing histidine with phenylalanine in haloalkane dehalogenase reverses the SN2 mechanism by remodeling the active site, enabling reversible reactions for sustainable transhalogenation.

This study identifies conformational dynamics as a key determinant of luciferase catalytic efficiency and light-emission stability, revealing a trade-off between oxygen affinity and enzyme longevity.

This study determines the crystal structures and dynamical behavior of an ancestral ABH-fold enzyme, revealing molecular features that enabled the transition from hydrolytic to oxygenolytic catalysis.

This paper enhances fluorinase catalytic efficiency by engineering mutants and optimizing reaction conditions, achieving a 60-fold increase in turnover rate.

The paper identifies the origin of a luciferase gene from haloalkane dehalogenases in brittle stars and shows parallel evolution of bioluminescence across distant species.

The paper analyzes the bioluminescence systems of three sea pen species using transcriptome data and biochemical assays, identifying key proteins and confirming their roles in light production.

This paper develops a deep neural network predictor, AggreProt, to identify aggregation-prone regions in proteins and demonstrates its utility in designing mutations to suppress aggregation.

The paper investigates how the C112R mutation in ApoE4 causes aggregation and shows that tramiprosate reduces this aggregation.