Detailed metabolic phenotyping of four tissue specific Cas9 transgenic mouse lines
Simon T. Bond, Aowen Zhuang, Christine Yang, Eleanor A.M. Gould, Tim Sikora, Yingying Liu, Ying Fu, Kevin I. Watt, Yanie Tan, Helen Kiriazis, Graeme Iain Lancaster, Paul Gregorevic, Darren C. Henstridge, Julie R. McMullen, Peter J. Meikle, , Brian G. Drew
This study demonstrates that long-term tissue-specific Cas9 expression in mice does not cause detrimental health effects or metabolic changes, supporting its use for gene-specific studies.
bioRxiv · Mar 31, 2021 · PreprintMolecular Biology