Yingying Liu

This paper demonstrates that injectable antisense oligonucleotides (ASO) can prevent and treat obesity in mice without significant loss of lean mass.

This study shows that the mouse brain lipidome changes with diet and metabolic state, particularly highlighting the impact of high-fat diets on lipid remodeling in the hypothalamus and brainstem.

This study shows that impairing polymerase gamma activity in cardiomyocytes leads to mtDNA instability, activates the integrated stress response, and causes severe cardiomyopathy with hepatopathy in mice.

The paper uses polygenic scores to identify plasma proteins causally linked to cardiometabolic diseases and finds some are targets for existing therapies.

This study demonstrates that long-term tissue-specific Cas9 expression in mice does not cause detrimental health effects or metabolic changes, supporting its use for gene-specific studies.