M. Rocio Servin‐Vences

Deleting Piezo1 and Piezo2 together in mice weakens uterine contractions and prolongs labor; uterine and sensory-neuron deletions act additively, and knockout uteri show reduced Gja1 (connexin43).

The paper identifies PIEZO2 as a key mechanosensitive ion channel in adipose sensory innervation and shows its role in regulating adipose tissue phenotypes.

The paper shows that PIEZO2 in dorsal root ganglia neurons regulates gut motility by sensing mechanical stretch, affecting gastrointestinal transit.

This study shows PIEZO channels are voltage-gated and can switch to purely voltage-gated mode, with disease mutations altering voltage sensitivity.