Author

Yunxiao Zhang

Scripps Research InstituteORCID 0000-0003-2145-4151Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Ardem PatapoutianiD· 3 shared M. Rocio Servin‐VencesiD· 3 shared Yu WangiD· 3 shared Darren J. LipomiiD· 2 shared Saba Heydari SeradjiD· 2 shared Sassan A MishkanianiD· 2 shared Sejal A KiniiD· 2 shared Verina H. LeungiD· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Ardem PatapoutianORCID

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Author profile →

4 papers

Recent·Most cited

PIEZO channels link mechanical forces to uterine contractions in parturition

Yunxiao Zhang, Sejal A Kini, Sassan A Mishkanian, Renhao Luo, Saba Heydari Seradj, Verina H. Leung, Yu Wang, M. Rocio Servin‐Vences, William Thomas Keenan, Utku Sonmez, Oleg Yarishkin, Manuel Sánchez-Alavez, Yuejia Liu, Xin Jin, Darren J. Lipomi, , Ardem Patapoutian

Deleting Piezo1 and Piezo2 together in mice weakens uterine contractions and prolongs labor; uterine and sensory-neuron deletions act additively, and knockout uteri show reduced Gja1 (connexin43).

Science · Nov 13, 2025Peer-reviewedPhysiology✦ In-depth digest

A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation

Yu Wang, Yunxiao Zhang, Verina H. Leung, Saba Heydari Seradj, Utku M. Sönmez, M. Rocio Servin‐Vences, Shuke Xiao, Xiangyu Ren, Leon Wang, Sassan A Mishkanian, Sejal A Kini, Jonathan Z. Long, Darren J. Lipomi, Ye Li, Ardem Patapoutian

The paper identifies PIEZO2 as a key mechanosensitive ion channel in adipose sensory innervation and shows its role in regulating adipose tissue phenotypes.

Cell Metabolism · Mar 6, 2025Peer-reviewedNeuroscience

Massively parallel in vivo Perturb-seq reveals cell type-specific transcriptional networks in cortical development

Xinhe Zheng, Boli Wu, Yuejia Liu, Sean Simmons, Kwanho Kim, Grace S. Clarke, Abdullah Ashiq, Joshua C. Park, Jiwen Li, Zhilin Wang, Liqi Tong, Wang Qizhao, Keerthi Thirtamara Rajamani, Rodrigo Muñoz-Castañeda, Shang Mu, , Xin Jin

This study develops a high-throughput in vivo Perturb-seq platform to analyze gene function across diverse cell types in the brain and peripheral nervous system, identifying cell type-specific transcriptional networks.

Cell · May 20, 2024Peer-reviewedNeuroscience

PIEZO2 in somatosensory neurons controls gastrointestinal transit

M. Rocio Servin‐Vences, Ruby M. Lam, Alize Koolen, Yu Wang, Dimah N. Saade, Meaghan C. Loud, Halil S. Kacmaz, Suzanne Frausto, Yunxiao Zhang, Arthur Beyder, Kara L. Marshall, Carsten G. Bönnemann, Alexander Theodore Chesler, Ardem Patapoutian

The paper shows that PIEZO2 in dorsal root ganglia neurons regulates gut motility by sensing mechanical stretch, affecting gastrointestinal transit.

Cell · Aug 1, 2023Peer-reviewedNeuroscience