Molecular BiologybioRxivPreprint
Severe perinatal hydrops fetalis in genome edited pigs with a biallelic five base pair deletion of the Marfan syndrome gene, FBN1
Hiu‐Gwen Tsang, Simon Geoffrey Lillico, Christopher Proudfoot…·KIM M. SUMMERS
This paper reports unexpected severe hydrops fetalis in CRISPR-Cas9 edited pigs with a FBN1 deletion, highlighting potential off-target effects and the need for comprehensive genomic analysis.
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