Author

Vittoria Monaco

CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)ORCID 0000-0002-7459-8733Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Maria MontiiD· 2 shared Achille IolasconiD· 1 shared Andrea R. BeccariiD· 1 shared Andrea ZalianiiD· 1 shared Angelo Sabato BocciaiD· 1 shared Biancamaria PierriiD· 1 shared Björn WindshügeliD· 1 shared Carmen Sorice· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Maria MontiORCID

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2 papers

Recent·Most cited

Resolving the pharmacological redox-sensitivity of SARS-CoV-2 PLpro in drug repurposing screening enabled identification of the competitive GRL-0617 binding site inhibitor CPI-169

Maria Kuzikov, Stefano Morasso, Jeanette Reinshagen, Markus Wolf, Vittoria Monaco, Flora Cozzolino, Simona Golič Grdadolnik, Primož Šket, Janez Plavec, Daniela Iaconis, Vincenzo Summa, Francesca Esposito, Enzo Tramontano, Maria Monti, Andrea R. Beccari, , Andrea Zaliani

The paper identifies CPI-169 as a competitive inhibitor of SARS-CoV-2 PLpro that targets the same binding site as GRL-0617, through a drug repurposing screening approach that accounts for redox-sensitivity.

bioRxiv · Oct 11, 2023 · PreprintMolecular Biology

Targeting ATP2B1 impairs PI3K/Akt/Fox-O3 signaling and reduces SARS-COV-2 replication in vivo.

Pasqualino De Antonellis, Veronica Ferrucci, Francesca Bibbò, Fathem Asadzadeh, Francesca Gorini, Angelo Sabato Boccia, Carmen Sorice, Roberto Siciliano, Roberta Russo, Immacolata Andolfo, Vito Alessandro Lasorsa, Sueva Cantalupo, Giovanni Paolella, Giovanna Fusco, Maurizio Viscardi, , Massimo Zollo

This study shows that inhibiting ATP2B1 with compound PI-7 reduces SARS-CoV-2 replication by lowering intracellular calcium levels and disrupting the PI3K/Akt/FoxO3 signaling pathway.

medRxiv · Sep 2, 2022 · PreprintGenetic & Genomic Medicine