This study identifies TRIM8 as a multifunctional protein involved in mitotic regulation through multi-omics analysis, showing its role in transcription, translation, and ciliary function.

bioRxiv · Mar 28, 2025 · PreprintCell Biology

Resolving the pharmacological redox-sensitivity of SARS-CoV-2 PLpro in drug repurposing screening enabled identification of the competitive GRL-0617 binding site inhibitor CPI-169

Maria Kuzikov, Stefano Morasso, Jeanette Reinshagen, Markus Wolf, Vittoria Monaco, Flora Cozzolino, Simona Golič Grdadolnik, Primož Šket, Janez Plavec, Daniela Iaconis, Vincenzo Summa, Francesca Esposito, Enzo Tramontano, Maria Monti, Andrea R. Beccari, , Andrea Zaliani

The paper identifies CPI-169 as a competitive inhibitor of SARS-CoV-2 PLpro that targets the same binding site as GRL-0617, through a drug repurposing screening approach that accounts for redox-sensitivity.

bioRxiv · Oct 11, 2023 · PreprintMolecular Biology

Targeting ATP2B1 impairs PI3K/Akt/Fox-O3 signaling and reduces SARS-COV-2 replication in vivo.

Pasqualino De Antonellis, Veronica Ferrucci, Francesca Bibbò, Fathem Asadzadeh, Francesca Gorini, Angelo Sabato Boccia, Carmen Sorice, Roberto Siciliano, Roberta Russo, Immacolata Andolfo, Vito Alessandro Lasorsa, Sueva Cantalupo, Giovanni Paolella, Giovanna Fusco, Maurizio Viscardi, , Massimo Zollo

This study shows that inhibiting ATP2B1 with compound PI-7 reduces SARS-CoV-2 replication by lowering intracellular calcium levels and disrupting the PI3K/Akt/FoxO3 signaling pathway.

medRxiv · Sep 2, 2022 · PreprintGenetic & Genomic Medicine

Long-chain polyphosphates impair SARS-CoV-2 infection and replication: a route for therapy in man

Veronica Ferrucci, Dae-Young Kong, Fatemeh Asadzadeh, Laura Marrone, Angelo Sabato Boccia, Roberto Siciliano, Giuseppina Criscuolo, Camilla Anastasio, Fabrizio Quarantelli, Marika Comegna, Ida Pisano, Margherita Passariello, Ilaria Iacobucci, Rosa Della Monica, Barbara Izzo, , Massimo Zollo

The paper investigates the anti-viral effects of long-chain polyphosphates (PolyPs) against SARS-CoV-2, showing they impair infection and replication by interacting with ACE2 and RdRp.

Science Signaling · Jul 6, 2021Peer-reviewedGenetics