Joost Peter Schanstra

Systematic comparison of gliflozins identifies a selective anti-calcifying effect of canagliflozin beyond canonical SGLT2 inhibition

This study compares gliflozins and finds canagliflozin uniquely reduces vascular calcification through mechanisms beyond SGLT2 inhibition, affecting VSMC metabolism and calcification.

Identification of the Col4a3-/- mouse as a model of chronic kidney disease-associated cachexia

The paper identifies the Col4a3-/- mouse as a model of CKD-associated cachexia, showing significant weight loss, muscle atrophy, and systemic inflammation.

Pan-fibrotic gene expression signature in major chronic diseases by integrative bulk and single-cell transcriptomic analyses

The paper identifies a conserved pan-fibrotic gene expression signature across liver, kidney, and heart fibrosis using bulk and single-cell transcriptomic data.

Integrative analysis of CAKUT multi-omics data

The paper integrates multi-omics data from CAKUT patients to identify collagen's role in disease development and provides containerized workflows for analysis.

Proteomic analysis of mouse kidney tissue associates peroxisomal dysfunction with early diabetic kidney disease

The paper identifies peroxisomal dysfunction as a key feature of early diabetic kidney disease through proteomic analysis in mice and human samples.

Haploinsufficiency of the mouse Tshz3 gene leads to kidney dysfunction

This study shows that Tshz3 haploinsufficiency in mice causes kidney structural, molecular, and functional abnormalities.