Author

Irene Sanchez-Martin

Cold Spring Harbor LaboratoryORCID 0000-0001-9202-2618Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

Lucas CheadleiD· 2 shared Adrian S. WoolfiD· 1 shared Ahmed Fatmi· 1 shared André Machado XavieriD· 1 shared Andrew J. SauriniD· 1 shared Ashesh D. MehtaiD· 1 shared Bharti KukrejaiD· 1 shared Brian Thomas KalishiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersDevelopmental Biology

Lucas CheadleORCID

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3 papers

Recent·Most cited

Developmental BiologyScience AdvancesPeer-reviewedSep 16, 2026

✦ In-depth digest

Maternal-fetal immune conflict contributes to male-specific impairments in a mouse model of neurodevelopmental disorders

Irene Sanchez-Martin, Bharti Kukreja, Paige Henderson…·Lucas Cheadle

A poly(I:C) dose at E12.5 causes placental junctional-zone breakdown, amniotic inflammation and developmental defects in a male-only subset of embryos within 24 hours, dependent on maternal IL-6.

3 citationstop 1%

mousehuman

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NeurosciencebioRxivPreprintFeb 18, 2026

Deciphering epileptogenic and activity-dependent gene programs in the human brain

Qianyu Lin, Chris J. Kang, André Machado Xavier…·Lucas Cheadle

The paper identifies activity-dependent gene programs in human epileptic brain tissue and finds that some responses are conserved with acute stimulation, while others suggest metabolic and inflammatory dysregulation in epilepsy.

DOI 10.64898/2026.02.18.706645

humanscRNA-seq

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GeneticsHuman Molecular GeneticsPeer-reviewedDec 15, 2021

Haploinsufficiency of the mouse Tshz3 gene leads to kidney dysfunction

Irene Sanchez-Martin, Pedro Magalhães, Parisa Ranjzad…·Laurent Fasano

This study shows that Tshz3 haploinsufficiency in mice causes kidney structural, molecular, and functional abnormalities.

3 citations

mousebulk RNA-seq

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